Anti-fibrinolytic activity and distribution of urinary trypsin inhibitor related substances.
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چکیده
منابع مشابه
Increased serum concentration of urinary trypsin inhibitor with asthma exacerbation.
The aim of the study was to determine whether the amount of urinary trypsin inhibitor (UTI) in serum, a degenerate induced by neutrophil elastase (NE), reflects the degree of bronchial inflammation in children with acute asthma exacerbation. The involvement of neutrophil-mediated inflammation plays as important a role as eosinophil-mediated inflammation in the pathogenesis of acute asthma exace...
متن کاملProtective effects of urinary trypsin inhibitor in experimental shock.
The effects of human urinary trypsin inhibitor (UTI) were studied in experimental shock models. Administration of 50,000 U/kg, i.v., of UTI protected against mortality from shock induced by burn, endotoxin or trauma. Aprotinin at a dose of 50,000 U/kg improved only endotoxin shock and showed a moderate but not significant effect on burn and traumatic shock. Administration of 50,000 U/kg, i.v., ...
متن کاملUrinary Trypsin Inhibitor, an Alternative Therapeutic Option for Inflammatory Disorders
Urinary trypsin inhibitor (UTI), a serine protease inhibitor, has been widely (and sometimes experiencely) used as a supportive drug for patients with inflammatory disorders such as pancreatitis, shock, and disseminated intravascular coagulation (DIC). Also, previous in vitro studies have demonstrated that serine protease inhibitors may have anti-inflammatory properties at sites of inflammation...
متن کاملSerum and Urinary Fibrinolytic Activity Related to the Hemorrhagic Diathesis in Irradiated Dogs
The urine and serum fibrinolytic activity were measured in dogs following whole body radiation ranging from 450 to 800 r generated by 1,000 kv. and 250 kv. machines. The fibrinolytic activity of the urine showed a precipitate rise 4 to 5 days before death in all dogs with pulmonary hemorrhage as the main cause of death. The fibrinolytic activity of the serum showed a similar rise, which was mos...
متن کاملUrinary trypsin inhibitor as a therapeutic option for inflammatory disorders
Introduction Urinary trypsin inhibitor, a serine protease inhibitor, has been widely used, particularly in Japan, as a drug for patients with acute inflammatory disorders such as pancreatitis, shock and disseminated intravascular coagulation. Previous in vitro studies have demonstrated that serine protease inhibitors may have anti-inflammatory properties beyond their inhibition of neutrophil el...
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ژورنال
عنوان ژورنال: Blood & Vessel
سال: 1989
ISSN: 0386-9717,1884-2372
DOI: 10.2491/jjsth1970.20.171